AC-11® SCIENCE

 

AC-11® and the Science of Phytonutrients

AC-11® and DNA Care

The Discovery of AC-11®

AC-11® Efficacy and Safety

The AC-11® “Rainforest Connection”

AC-11® Patent Protection and Product Availability

Important Links to AC-11® Science

 

AC-11® and The Science of Phytonutrients

The term "phyto" originates from a Greek word for “plant.”  Phytonutrients are the organic components of plants that promote health in humans and animals.  Fruits and vegetables, grains, nuts, teas, etc. are all rich in phytonutrients.

A source of amazing phytonutrients unknown to exist elsewhere in the world is found in the rainforests of Brazil and Peru, often called the “living pharmacy” for the depth, variety and complexity of the plant and animal life forms that have developed there over many thousands of years, and for the breakthrough discoveries that researchers in biochemistry and pharmacological medicine continue to make in studying the wondrous ecosystem of this region.

Safe, all natural and water soluble AC-11® (formerly C-Med-100®) is a patent-protected, bioactive rainforest plant extract that helps the body to repair sun and environmental stress-related damage to DNA, and slow down the process of skin aging.  AC-11® is the perfect joining of the rainforest’s secrets with the miracle of today’s advancements in phytonutrient science.

AC-11® and DNA Care

AC-11® (formerly known as C-Med-100®) derives from Uncaria tomentosa, a plant indigenous to the rainforest.  We create AC-11® using a patented, wholly proprietary “aqueous hot water extraction” and purification process standardized to a minimum of 8% Carboxy Alkyl Esters (CAE) concentration. 

CAEs are the complex molecular chains that form the primary active components of AC-11®.  They are responsible for approximately 90% of the biological activity in AC-11® relating to DNA repair and immune enhancement.

Although the exact mechanisms of action are not all completely understood, our scientists believe that when the body is subjected to stress that may affect the integrity of the DNA (overexposure to the sun for example), AC-11® helps activate enzymes that are instrumental in the repair processes.  In a series of peer reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, we have shown that AC-11® helps the body’s natural ability to repair DNA.

AC-11® studies moreover show that the CAEs unique to our product not only enhance significantly the body’s natural ability to repair damaged DNA, but also measurably improve natural collagen III production in the skin. 

Collagen III is a form of collagen associated with soft, supple, youthful-looking skin.  As we age, our cells gradually produce less collagen III than they did when we were young.  However, laboratory research shows significant, measurable increases in collagen III production in adult skin cells treated with AC-11®.

AC-11® also helps to normalize the expression of NF-KB in the cells, thereby regulating cellular response to inflammation.  NF-KB is a nuclear transcription factor that influences numerous gene-encoding proteins important in apoptosis (programmed cell death), inflammation and cellular growth.  A normal expression of NF-KB minimizes the hazards of excessive oxidative stress.  An over-expression of NF-KB triggers increased inflammation.

In a human study, AC-11® demonstrated a positive effect on lymphocytes, increasing their life span and, by implication, enhancing the body’s immune system.

AC-11® differs from all other Uncaria tomentosa products, some of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct by virtue of the Optigenex patented process.  AC-11® is standardized, pure, water-soluble and micro-filtered to contain only low weight molecules (<10,000 Daltons).  AC-11® is relatively alkaloid free (<0.05%) and is the only product available anywhere containing a patented class of CAE actives shown by extensive research to have healthy aging and natural DNA repair enhancement properties.  No other Uncaria tomentosa product can make these claims.  AC-11® moreover has been studied for efficacy and safety for over ten years.

The Discovery of AC-11®

The method by which AC-11® is formulated was discovered by Ronald W. Pero Ph.D., a widely published scientist, university professor emeritus and expert in the fields of human biochemistry and DNA research. Dr. Pero’s work involving AC-11® was based on more than 30 years of research, including extensive field research on indigenous plant life in the Amazon region of South America.

AC-11® Efficacy and Safety

AC-11® is backed by an extensive Efficacy and Safety profile.  Pure, bioactive AC-11® is the only known plant extract in the world shown by research studies to enhance our natural DNA repair processes.  In fact, few other nutraceutical or cosmeceutical plant extract ingredients have been subjected to as much rigorous scientific study as has AC-11®.

As sold, AC-11® strictly conforms to the unique specifications set by our manufacturing methods and standardization claims.  We perform all of the standard industry-accepted tests to ensure that our product meets requirements for sale in the United States and other centers of commerce throughout the world.  To make AC-11® we engage the services of Centroflora Group in Botucatu, Brazil, a U.S. Department of Agriculture approved and ISO 9002 certified facility operated in accordance with FDA (U.S. Food and Drug Administration) regulations and GMP (Good Manufacturing Practices) standards, and one of the finest facilities in the world for the production of phytotherapic extracts.  Using proprietary equipment conceived and developed by our company, AC-11® is manufactured at Centroflora under state-of-the-art conditions and we warrant our product’s conformance to its specifications as well as to applicable governmental regulations.

The LD-50 of AC-11® is greater than 8,000mg/kilogram. The recommended daily dosage of AC-11® for internal use in “stand alone” form is between 350 and 700mg (250 mg. minimum in products combining AC-11® with other active ingredients) for a person weighing 150-200 lbs. (70-90 kilograms). AC-11®’s purity is due to the clean, contaminant and chemical toxin-free rainforest environment in which the plant is harvested and processed, as well as the patented Optigenex molecular sieving (filtration) process. By contrast, mild toxicity with long term use often is observable in other “Uncaria” products, especially the water-insoluble, alkaloid based extracts.

The AC-11® “Rainforest Connection”

AC-11® is derived naturally from Uncaria tomentosa, a vine that grows wild in the Amazon rainforest.  We harvest the vine in an ethical manner under the authority of the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA). This ensures future maintenance of a natural balance in the rainforest.  Authorization is granted through an ongoing sustainable management project directed by the government and based upon existing local herb availability whereby the amount of inner bark approved for harvesting is set.  The harvest is taken (cut) at a point on the plant approximately three feet above the ground; the plant is then capped to ensure integrity of the root structure and rapid regeneration of the vine.  Additionally, new saplings of the Uncaria tomentosa vine are planted in a precise manner to ensure the continued viability in the harvesting area.  Optigenex moreover works in cooperation with the Floravida Institutes (Brazil) guidelines for biodiversity conservation, environmental education and local community social inclusion.

AC-11® Patent Protection and Product Availability

Currently there are six (6) individual patents issued by the United States Patent Office for AC-11®: U.S. Patent Nos. 6,039,949, 6,238,675 B1, 6,964,784 B2, 6,361,805 B2, 7,579,023 B2 and 7,595,064 B2. Our portfolio of patents covers manufacturing, composition and claims, including specifically the patented AC-11® claim for DNA repair. Additional domestic and foreign patent applications are pending.

AC-11® is manufactured and sold in powdered form for ingestible use as a stand-alone dietary supplement or in combination formulas with vitamins, minerals and other nutritional supplements. We also formulate finished products for topical use and can make available for approved customers with adequate facilities and product formulation expertise AC-11® in a stable, encapsulated form designed for optimal delivery in topical applications. AC-11® is registered as a dietary supplement under the Dietary Supplement Health and Education Act (DSHEA) and listed under its INCI (International Nomenclature of Cosmetics Ingredients) names Maltodextrin and C1-8 Alkyl Tetrahydroxycyclohexanoate with the Personal Care Products Council (formerly the Cosmetic, Toiletry and Fragrance Association or CTFA). AC-11® moreover is approved for sale in numerous foreign countries.

Important Links to AC-11® Science

Please Note: Many of the foundational studies, peer reviewed scientific papers and journal articles related to AC-11® science refer to AC-11® by its formerly known name, "C-Med-100®".

Some of the more important studies, papers and articles about AC-11®/C-Med-100® are the following:

Dietary quinic acid supplied as the nutritional supplement AIO + AC-11 leads to induction of micromolar levels of nicotinamide and tryptophan in the urine.

Chemotherapy Induced Leucopenia, Animal Study, Phytomedicine, 2000
Download PDF:

Enhanced DNA Repair and Immune Function, Animal Study, Ethnopharmacology, 2000
Download PDF:

Enhanced Response to Vaccine, Human Study, Phytomedicine, 2001
Download PDF:

Enhanced DNA Repair, Human Study, Phytomedicine, 2001

Download PDF:

AC-11® in Combination with Synergistic Nutritional Supplements, Human Study, Anti-Aging Medicine, 2002
Download PDF:
Inhibition of Tumor Cell Proliferation, Animal Study, International Immunopharmacology, 2003
Download PDF:

Prolonged Lymphocyte Survival, Animal Study, Phytomedicine, 2003

Download PDF:

AGI Dermatics Topical Study, 2004 Unpublished

Download PDF:

DNA Repair and Weight Loss, Human Study, Phytomedicine, 2005

Download PDF:

Estee Lauder-Sponsored Topical Study, Phytotherapy Research, 2006

Download PDF:

DNA Repair Adjuvants, Skin & Aging, 2006

Download PDF:

Botanical Extract Protects Against UV, Dermatology Times, 2006

Download PDF:

Review of DNA Repair Adjuvants and Selected Natural Anti-Oxidants, Dermatology Online Journal, 2007

Download PDF:

Interview with Dr. Noah Scheinfeld, Whole Foods, 2008
Download PDF:

Laboratoire BIO-EC (France) Summary of Study: Skin Health and Benefits, 2008 Unpublished

Download PDF:

C-Med - 100: a novel, natural compound that averts inflammation and protects natural immunity through DNA

Download PDF:

DNA Repair. Maintaining performance and appearance at any age.

Download PDF:


Journal Articles


An active ingredient of Cat's claw water extracts: Identification and efficacy of quinic acid.

Download PDF:

Anti-inflamatory activity of two different extracts of Uncaria Tomentosa (Rubiaceae)

Download PDF:

Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria Tomentosa

Download PDF:

Quinic acid is a biologically active component of the Uncaria Tomentosa extract C-MED 100

Download PDF:


Reports


Activar Day Cream: Repeated insult patch

Download PDF:

Activar Eye Cream: Repeated insult patch

Download PDF:

Activar Eye Cream: The hen's nest egg test-utilizing the chorioallantoic membrane (HET-CAM)

Download PDF:

Activar Night Cream: Repeated insult patch test

Download PDF:

Salmonella typhimurium reverse mutation assay: Ames test

Download PDF:


Related Articles


Antioxidant metabolism induced by quinic acid: Increased urinary excretion of tryptophan and nicotinamide.

Download PDF:

DNA repair enhancedment by a combined supplement of carotenoids, nicotinamide, and zinc.

Download PDF:

Health consequences of catabolic synthesis of hippuric acid in humans.

Download PDF:

In vivo treatment of humans with quinic acid enhances DNA repair and reduces the influence of lifestyle.

Download PDF:

Low serum thiol levels predict shorter times-to-death among HIV-infected injecting drug users.

Download PDF:

Markers of DNA repair and susceptibility to cancer in humans: An epidemiologic review.

Download PDF:

Metabolic syndrome, hormones, and maintenance of T cells during aging.

Download PDF:

Quantitative analytical method development for the assessment of bioactive quinic acid-type esters and free quinic acid in dietary supplements.

Download PDF:

Reduced level of serum thiols in patients with a diagnosis of active disease.

Download PDF:

Serum thiols as a surrogate estimate of DNA repair correlates to mammalian life span.

Download PDF:

Surrogate indication of DNA repair in serum after long term chiropractic intervention-A retrospective study.

Download PDF:

The role of DNA damage repair in aging of adult stem cells.

Download PDF:

Cat's claw.

Download PDF:

Efficacy and safety of ac-11

Download PDF:

Historical development of Uncaria preparations and their related bioactive components.

Download PDF:

The immunomodulatory properties of C-MED 100 and extract of the plant Uncaria Tomentosa.

Download PDF:

Our company's proprietary molecular sieving equipment is used for isolating and concentrating Carboxy Allkyl Esters (CAEs), the primary active ingredient in our patented, all natural, plant derivative product AC-11®.